Tory Brennan, niece of acclaimed forensic anthropologist Temperance Brennan, is the leader of a ragtag band of teenage "sci-philes" who live on a secluded island off the coast of South Carolina. When the group rescues a dog caged for medical testing on a nearby island, they are exposed to an experimental strain of canine parvovirus that changes their lives forever.
As the friends discover their heightened senses and animal-quick reflexes, they must combine their scientific curiosity with their newfound physical gifts to solve a cold-case murder that has suddenly become very hot — if they can stay alive long enough to catch the killer's scent. Fortunately, they are now more than friends; they're a pack. They are Virals!