When all the humans in his world disappear, Max, a yellow Labrador Retriever, begins the search for his family. He knows that if he can just find Madame Curie, a wise old black Lab, she'll be able to help. Madame had a premonition of astonishing events to come; she might know where Max's family is. But Max can't make the journey alone. Joined by friends Rocky and Gizmo, Max sets off to find Madame. Along the way, the trio must face a pack of angry wolves, forage for food in a land where kibble is akin to gold, befriend a house full of cats, and outsmart a gang of subway rats. Ultimately, they'll have to escape from the biggest threat of all: the Corporation, a supposed "perfect" society for dogs and by dogs, where nothing is quite as it seems. This thrilling adventure is a tale of three unlikely friends on an epic quest to find their people and bring them home.