George is alone again with his Grandma. Most Grandmas are sweet and friendly — but not George's Grandma! She's nasty, she yells at George all the time, and she might even be a witch! George has had enough of his grouchy Grandma. He thinks the solution might be to replace her regular medicine with some marvelous medicine that he will make out of all sorts of ingredients. George's medicine works so marvelously well that Grandma — and his family — will never be the same again!