Peter Parker is a typical teenager living in New York City. His timid demeanor and passion for science make him a perfect target for high school bullies like all-star football player Flash Thompson. But all that changes when his class takes a field trip to Empire State University, where a radioactive spider bites Peter and he starts to transform! Suddenly he has incredible new spider-like powers, but the awkward teen must learn how to cope with abilities that set him even further apart from his peers. And when Peter endures a personal tragedy that teaches him a harsh lesson about responsibility, can he find the inner strength to triumph over adversity and become something Amazing?